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Dog FAQ

How old must my puppy be to receive an Optimal Selection™ test?

 

 

DNA testing can be performed on a dog of any age, and Optimal Selection™ results will not change with age. Blood samples may be taken from puppies as soon as they are large enough for a veterinarian to obtain 1-2 mLs of blood (less than one teaspoonful) safely. Swab samples can also be taken from young puppies, but it’s best to wait until the puppy is weaned (to prevent contamination from the dam’s milk or skin) or nursing infrequently enough that a cheek sample may be taken three hours after last nursing or food.

 

Will my dog’s Optimal Selection™ test results change as they get older?

No. Although mutations can occur within individual cells throughout life, a dog’s DNA does not change with age. Some specific tests may be added or removed as technology changes.

 

Will Wisdom Panel certify untested puppies classified as clear by parentage?

No. We recommend always testing the dogs that will be bred. It is best to rely on "Clear by parentage" for pets or dogs that won't be bred.

 

If I submit a sample now and a new test becomes available in the future, will you be able to use the same sample to update my results?

No. A new sample will be needed in the event you wish to update results on a previously tested dog, as all new genotyping will need to be performed.

 

What’s the difference between a linked marker test and a direct mutation test?

Linked marker tests identify a gene or variant by a “genetic fingerprint” that is almost always associated with the mutation. On the other hand, direct mutation tests detect the presence or absence of the exact mutation that results in a particular disorder or trait. Both types of testing approaches provide information about the genetic status of an individual animal with high reliability.

 

How do I air dry the swabs without contaminating them?

The swab will only become contaminated if it comes into contact with other dogs, people, or dirty surfaces. So, you should dry the swab with the bristles in the air (not touching any surface). Both swabs should be air-dried for at least five minutes and then reinserted into the protective 

sleeve, ensuring the bristles are completely covered. (Very important: do not reseal the sleeve, as this can promote bacteria/fungus growth.) Ship the samples at your earliest convenience, and rest assured that they will not be affected by extremes in temperature.

 

I have a deceased dog. Can I still test?

Yes, we accept purified archived DNA and frozen semen for deceased dogs. (A minimum of 50 microliters is required for semen samples, so used semen straws do not provide adequate DNA.) Special shipping requirements and charges apply for non-traditional samples, and no refunds are provided in the event of sample failure. Please contact our customer service team for details at info@wisdompanel.com or 855-619-1884.


What type of samples do you accept? How much of the sample is needed?

In the absence of cheek swabs, a variety of samples types may be used—including:

  • 1-2 mL fresh, whole (unclotted) blood in an EDTA-top tube
  • 1-2 mL frozen blood, 2 bristle (cytology) swabs
  • Semen (minimum 50 microliters, leftover from used semen straw does not provide adequate DNA)
  • Tissue (frozen, not fixed, approximately sugar cube size)

Special shipping requirements and charges apply for non-traditional samples, and no refunds are provided in the event of sample failure. Please contact our customer service team for details at info@wisdompanel.com or 855-619-1884.


I am in Canada. Do you ship to Canada?

Yes! Optimal Selection™ Canine is available to all Canadian customers (except those in the province of Quebec, due to packaging requirements). Canadian kits ship via UPS to reduce customs delays. Shipping is $15 USD for the first kit and $5 USD for each additional kit per order. All prices are listed in USD but converted to CAD upon payment.


How long does it take to get my results?

Most Optimal Selection™ results arrive around 2-3 weeks after our lab receives your dog's DNA sample. That said, extended times sometimes occur due to circumstances beyond our control (e.g., volume at the lab, holidays, illnesses, natural disasters). You'll get an email notification when your results are ready. Please note—results are digital and available in your online account only. No physical report will be mailed, but you may download a printable technical report from your account.


Where do I find the sample ID number?

The sample ID is located on the short side of your Optimal Selection™ kit.

On older versions of the kit, it may be located elsewhere. If you have a legacy kit, please contact customer service at info@wisdompanel.com or 855-619-1884.


How do I activate my dog’s sample?

If this is your first kit, simply go to https://optimal-selection.com/ , select “Activate” in the upper right, and follow the prompts. If you already have an account for any test (Optimal Selection™ Dog or Cat, MyDogDNA, MyCatDNA, or Wisdom Panel™ tests), select “Sign In” and, once in your account, select “Testing a new family member.” After you activate your kit, you’ll be able to track your sample and get updates throughout the test analysis process.


I forgot to activate my kit. What do I do now?

We may be able to help. Please contact our customer care team at info@wisdompanel.com or 855-619-1884.


How do I get a copy of my dog’s Technical Report if my name is not on the account?

We have a strict privacy policy that requires written consent from the pet owner (assigned during kit activation) before we may share any information about a specific test with someone who is not on the account. For this reason, reports are emailed only to the email address on file, and we can’t accept changes to account information unless requested by the listed owner.


Do weather or temperature extremes affect the quality of the swab samples in transit?

Weather is unlikely to impact sample quality. Cheek cell samples are a very stable way to collect DNA for testing, and they can withstand normal ambient temperature changes.


I mailed my test a week ago, and you haven't received it yet. Should I worry?

Not to worry! Transit times vary throughout the year due to several factors (e.g., holidays, weather, natural disasters) and may take anywhere from 5-10 business days.  When samples arrive at our lab, we check them in individually to avoid contamination or mix-ups. Once we begin processing your sample, the status will change to "Sample Received," and you will be alerted via email. If you would like to track your sample while it's in transit to our lab, please note the USPS tracking number on your kit’s prepaid shipping label before putting it in the mail.


How do I monitor processing of my sample?

You can track the progress of your sample online by signing into your account.


I didn't see the warning about waiting two hours after eating and took my dog's sample right after they ate dinner. Is it ruined?

We try to avoid having food particles on the swabs, as they may encourage bacterial growth in transit. Your sample is likely fine. But if there are obvious food particles on the swab or if you have concerns, please reach out to our customer service department at info@wisdompanel.com.


When I track my sample, it says "Delivered" by USPS, but the Test Status Checker doesn't say that you've received it yet. Why?

The USPS tracking will show when the package gets delivered to the post office in Lincoln, NE. From there, the kits travel via courier to the lab on the next business day. Each kit is then checked in individually to avoid any risk of contamination. For these reasons, there will sometimes be a delay of a few days between delivery and sample processing. Rest assured, this additional time has not been found to affect sample quality at all.


What breeds can be tested on Optimal Selection™?

All dog breeds can be tested on Optimal Selection and receive disorder, trait, and diversity results. If there are known disorders for the breed, they will be highlighted in the report. Diversity information specific to your dog’s breed will be provided once we’ve tested enough dogs of the particular breed. Until then, their diversity  score will be relative to all purebreds in our database.


When was Optimal Selection™ Canine first launched?

The first Wisdom Health (formerly Mars Veterinary) canine breeder DNA test launched in 2010 under the name Optimal Selection. It was a blood-based test designed to determine which matings would produce maximum genetic diversity in the offspring (similar to breeding for low Coefficient of Inbreeding [COI]). In 2015, Wisdom Health partnered with Genoscoper Laboratories and began also offering an extensive genetic disease and trait testing panel.


My dog’s breed is not listed in the dropdown options during kit activation. How can I get the breed added?

You are welcome to select “Other breed” and enter the name. You may also email our customer service team at info@wisdomhealth.com to nominate your breed for addition. (We update our breed list every 6-12 months.) In your email, please provide some background information on your breed. If the breed is rare, the Wisdom Panel team may be able to support early adoption of health testing in your breed.


You used to report on cord1-PRA/crd4. Where did it go?

Cord1-PRA and crd4 refer to the same genetic disorder. To be consistent with other similarly named disorders and prevent confusion, the current name for the condition is now crd4. For a progressive retinal atrophy (PRA), the condition is unusual in that its manifestation appears to be genetically complex. Wisdom Panel’s team of scientists contributed to the discovery of both the genetic variant in RPGRIP1—which has been referred to as the primary risk gene for crd4—and a gene variant in MAP9—which has been shown to cause an early-onset form of the disorder in Dachshunds. For unknown reasons, dogs with two copies of the risk variant in RPGRIP1 do not always develop abnormal vision. And recent research suggests at least one more gene variant likely contributes to disease development risk. Based on this research, and to provide the most informative result for breeders, we decided to halt reporting of this disorder until a combined predictive risk score can be reported based on both RPGRIP1 and MAP9 genotypes.


Why do you offer tests pre-publication?

Bringing research to publication can take several years depending on the nature of the disorder or gene variant under study. The Wisdom Panel team partners with many veterinary research groups to accelerate research on behalf of dogs. In cases where the pre-publication data strongly suggest association with a disorder or trait—or when a partnering breed group indicates high interest in a genetic test (and understands potential limitations)—we may choose to provide pre-publication testing information early to breeders to inform breeding decisions. When we do this, we provide as much information as we can about the gene variant. We also share what we do not know so that the result’s significance may be interpreted properly. We encourage our research partners to publish their findings—and we do the same ourselves—so that the breeder and research communities can benefit.


I want to transfer my results to another breeder. When will this feature be restored?

Currently, we have no plans to restore this feature but are considering it for future development. For the time being, you can use the share functionality to share the results with the new owner. 


Do you test for cocoa (formerly “untestable chocolate”) in French Bulldogs?

Optimal Selection™ Canine does not include cocoa testing at this time. Unlike chocolate (also called liver), cocoa coloration is caused by a gene variant in HPS3, first reported in summer of 2020. We will offer this test with the next Optimal Selection™ panel update—or earlier if a linked marker test can be validated. If you have a French Bulldog previously tested with Optimal Selection™ or MyDogDNA and your dog has been tested for cocoa and is positive for one or two copies of the trait, we would love your help as we develop a linked cocoa marker test. If you’re interested, please email us at info@wisdompanel.com.


Do you test for chondrodystrophy (CDDY) with intervertebral disc disease (IVDD) risk?

Chondrodystrophy (CDDY) with intervertebral disc disease (IVDD) risk is caused by a retrogene insertion on chromosome 12 (CFA12-FGF4RG). This is not to be confused with breed-defining chondrodysplasia, which—though caused by the same retrogene insertion on chromosome 18—is not associated with increased risk of IVDD. We do not currently report on CDDY with IVDD risk but we’re actively working with its discoverer, Dr. Danika Bannasch at UC Davis, to offer this test. We also intend to create opportunities to participate in further research, as we know how devastating IVDD can be. Until then, we encourage you to test with UC Davis for this variant. Much remains to be determined regarding disease risk and informed individualized treatment recommendations. We greatly appreciate your support of this research.


Why do you no longer offer testing for primary hereditary cataract (PHC, HSF4-2) in Australian shepherd dogs and Miniature American Shepherds?

Wisdom Panel is committed to providing trustworthy results to breeders. Due to recent updates to our testing process—and because this particular genetic variant is challenging to detect using Optimal Selection™ technology—testing is only available from our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission is required. Please see the Help section on the ordering site for guidance on best swab types to use.


Why do you no longer offer testing for Canine Cyclic Neutropenia (Cyclic Hematopoiesis, Grey Collie Syndrome, CN)? 

To ensure we’re providing the most trustworthy results to breeders, we have temporarily paused reporting on this disorder until an updated reporting process has been fully validated.


Why do you no longer offer testing for Glycogen Storage Disease Type II ( Pompe's Disease, GSD II) in the Finnish Lapphund, Swedish Lapphund, and Lapponian Herder? 

To ensure we’re providing the most trustworthy results to breeders, we have temporarily paused reporting on this disorder until an updated reporting process has been fully validated.


Why do you no longer offer testing for Primary Open Angle Glaucoma, (POAG) in the Beagle?

To ensure we’re providing the most trustworthy results to breeders, we have temporarily paused reporting on this disorder until an updated reporting process has been fully validated.


Why do you no longer offer testing for Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis (CKCSID) in the Cavalier King Charles Spaniel?

Wisdom Panel is committed to providing trustworthy results to breeders. Due to recent updates to our testing process—and because this particular genetic variant is challenging to test for using Optimal Selection™ technology—we have chosen to pause reporting on this disorder until an alternative testing protocol can be offered.


Why do you no longer offer testing for Neuronal Ceroid Lipofuscinosis 10, (NCL10) of the American Bulldogs?

To ensure we’re providing the most trustworthy results to breeders, we have temporarily paused reporting on this disorder until an updated reporting process has been fully validated.


Why have the known disorders for my dog’s breed changed?

New research constantly reveals new genetic discoveries associated with disease predisposition among dog breeds. Wisdom Panel’s team of researchers and scientists actively contribute to this body of knowledge and review the findings of our colleagues to provide best-in-class testing to breeders. If we note a pattern of genetic disorder results in a certain breed and see adequate evidence of clinical significance, we will add to the list of known disorders for the breed to elevate breeder awareness. Breed-specific disorders can also change with testing panel updates, which occur on a regular basis. Rarely, testing panel updates may cause a particular test to fail our rigorous reporting quality standards. And new research sometimes suggests additional discovery work is necessary before reporting on a particular gene variant. In such cases, we may remove a disorder from our test offerings for a time.


What is the difference between Wisdom Panel products (e.g., Wisdom Panel Essential, Premium, 4.0, or Health) and breeder testing?

Though they offer various levels of health and trait testing, Wisdom Panel products focus on ancestry testing for pet owners. Our breeder products, on the other hand, are tailored for breeders. So, ancestry testing is not included, but we do include the most extensive health, trait, and diversity reporting available. For example, Collie Eye Anomaly (CEA) and Progressive Rod Cone Degeneration (prcd-PRA) are only reported in our breeder products—and at no additional charge. Optimal Selection™ Canine is offered exclusively on https://www.optimal-selection.com (it cannot be purchased on wisdompanel.com) for less than Wisdom Panel Premium because it does not include ancestry testing.


Do you test for dilution?

Yes, we test for three forms of dilution in Optimal Selection™: dilution type 1 (d1), dilution type 2 (d2), and dilution type 3 (d3). Dilution type 1 is the most common, and we detect it via a linkage test. Dilution types 2 and 3 are direct tests but are much less commonly observed because they are breed-specific. Please note that rare, yet-to-be-discovered genetic variants are also known to cause dilution. If your dog is dilute but was not reported as carrying two copies of one or more dilution variants, we encourage you to reach out to our customer service team so we may include your dog in future research.


Why are some tests no longer included in Optimal Selection™? 

Breed-specific tests may change with testing panel updates, which occur on a regular basis. Rarely, testing panel updates may cause a particular test to fail our rigorous reporting quality standards. And new research sometimes suggests additional discovery work is necessary before reporting on a particular gene variant. In such cases, we may remove a disorder from our test offerings for a time.


What coat color tests do you provide?

Optimal Selection™ Canine screens for over 40 traits. View the complete list of coat color tests here.


Do you test for merle insertion (SILV SINE) length?

No, Optimal Selection™ Canine tests for the presence or absence of the merle SINE insertion in the SILV gene. The length requires a secondary, specialized test (fluorescent fragmentation analysis). Dogs that have no visible merle coloration but show a positive result upon testing are likely carrying a shortened (truncated) merle allele. Tilia Laboratories in Europe offers confirmatory testing for the presence or number of truncated merle alleles and for m/Mc/Mc+/Ma/Ma+/M/Mh determination.


You detected one or two copies of merle, but my dog does not show merle coloration. Why is this?

Optimal Selection™ Canine tests for the presence or absence of the merle SINE insertion in the SILV gene. Often found in breeds that have carried merle for many years, the insertion can become shortened (truncated) due to copying errors that occur when gene information is passed down to offspring. Mutations within an individual can also result in that dog carrying two or more merle allele lengths. This is called “mosaicism.” Shorted merle insertions usually: 

  • Do not produce a visible coat color change
  • Are not thought to pose a risk of impaired vision or hearing
  • Do not spontaneously revert to a normal merle allele length

Optimal Selection testing will detect all lengths of merle alleles and report presence of these as “merle” without further details. There are also rare cases in which the merle insertion has little effect on coloration in that individual, but is not shortened. Offspring that inherit this variant from a parent can show normal merle coloration, even though their parent doesn’t. To rule out cryptic or atypical merle, a secondary, specialized test (fluorescent fragmentation analysis) is required. Tilia Laboratories in Europe offers confirmatory testing for the presence or number of truncated merle alleles and for m/Mc/Mc+/Ma/Ma+/M/Mh determination.


You detected two copies of chocolate for my dog, but they are not chocolate. Why is this?

Optimal Selection™ Canine detects four chocolate variants: variant 1 (bc), variant 2 (bs), variant 3 (bd), and variant 4 (basd). Variants 1, 2, and 4 replace the dominant black allele. But variant 3 is unique in that it can also occur on a chromosome that is already carrying another chocolate variant from the same parent. To show chocolate, a dog must inherit at least one chocolate variant from both parents. Dogs that inherit two copies of chocolate from one parent and no copies from the other parent will produce black pigment—even though they have two copies of chocolate. Additional rare, unknown variants are possible, and “non-testable chocolate” (cocoa) of French Bulldogs is not caused by the chocolate locus. 


I tested parents and offspring with Optimal Selection™ or MyDogDNA, but the disorder or trait results do not appear to agree with what I was expecting. What causes this?

The most common cause for discrepancies between parents and offspring is that they were analyzed with different versions of the test. So, the sire or dam were screened for a slightly different set of disorders or traits compared to the offspring. Looking closely at all results will generally indicate if the test(s) in question were actually performed for both parent and offspring. Another common cause is that the test was mislabeled before submission—usually when more than one dog’s sample was collected at the same time. Genetic results are rarely inconsistent due to pedigree errors or true laboratory errors. We care deeply about the accuracy and quality of our results. If you have a concern, please contact us at info@wisdompanel.com. Our specialists will review the data and recommend an appropriate course of action.


I tested some of my dogs with Optimal Selection™ and some at another lab, and the results do not appear to agree. What should I do?

To confirm that the same test was actually performed at both labs, we first recommend a close comparison with help from the testing laboratories. At this time, there are limited national or international standards for veterinary genetic testing. So, test nomenclature, type, quality, reproducibility, and procedure varies from laboratory to laboratory. Wisdom Panel follows recommended best practices, has been offering veterinary genetic testing for over 15 years, and has built a reputation for high testing standards to mitigate risk of error. We care deeply about the accuracy and quality of our results. If you have a concern, our specialists will review the data and recommend an appropriate course of action. Wisdom Panel cannot vouch for the accuracy of other laboratory results but will provide counsel to owners based on the information available.


Why does my technical report not show my dog’s breed-specific disorder results?

Breed-specific results in the web and technical reports are only provided if you designated your dog’s breed in their profile. You may enter this information during kit activation or at a later time by visiting the dog’s profile in your account and selecting a breed. This will also update the technical report, which you can then download. If your dog’s breed does not have any known disorders, the full list of disorders tested will still be displayed.


Why does my dog’s diversity graph compare him/her to “all purebred dogs” but not his/her breed?

Breed-specific results in the web and technical reports are only provided if you designated your dog’s breed in their profile. You may enter this information during kit activation or at a later time by visiting the dog’s profile in your account and selecting a breed. If you have a rare breed for which we have fewer than 30 individuals in our database, your dog’s diversity score will be relative to all purebred dogs until we’ve collected enough reference samples.


I have an Irish Setter or Irish Red and White Setter and need Canine Leukocyte Adhesion Deficiency (CLAD), type I testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Glen of Imaal Terrier and need Cone-rod Dystrophy 3, (crd3) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Poodle or Poodle hybrid and need Day Blindness/Retinal Degeneration (DB/RD) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Collie or Shetland Sheepdog and need Dermatomyositis (DMS) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Golden Retriever and need Golden Retriever Progressive Retinal Atrophy 2 (GR PRA 2) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Golden Retriever and need Neuronal Ceroid Lipofuscinosis 5 (NCL5) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Labrador Retriever and need Oculoskeletal Dysplasia 1 (OSD1) or Dwarfism-Retinal Dysplasia 1 (DRD1) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use. 


I have a Samoyed and need Oculoskeletal Dysplasia 2 (OSD2) or Dwarfism-Retinal Dysplasia 2 (DRD2) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have an Australian Shepherd Dog and need Primary Hereditary Cataract (PHC) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a French Bulldog, Boston Terrier, or Staffordshire Bull Terrier and need Primary Hereditary Cataract (PHC) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I have a Rough or Smooth Collie and need Rod Cone Dysplasia 2 (rcd2) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use.


I need Rod Cone Dysplasia 4 (rcd4) testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use. This disorder is found in the Australian Cattle Dog, Danish Pointing Dog, English Setter, Gordon Setter, Irish Setter, Irish Red and White Setter, Japanese Spitz, Llewellyn Setter, Miniature Poodle, Polish Lowland Sheepdog, Small Munsterlander, Standard Poodle, Tibetan Terrier. 


I have a Miniature Schnauzer and need Type B PRA testing. Do you offer this test?

Yes. This test requires specialized analysis, so it is available on our a la carte breeder test website as a kitless test (owner supplies the swabs). This test is not available as part of the Optimal Selection™ testing panel. So, separate payment and swab submission are required. Please see the Help section on the ordering site for guidance on the best swab types to use. An updated version of the Type B PRA of Miniature Schnauzers test, this a direct test for the HIVEP3 mutation and replaces the previous linkage test. Recent scientific research has revealed a new candidate causal mutation for this condition in the HIVEP3 gene (a previous candidate was found in the PPT1 gene). We are now offering this test, as the HIVEP3 mutation offers increased accuracy compared to the previously offered PPT1 linkage test—according to the published literature and our in-house validation studies.


When will printable reports be available? 

The Technical Report feature is now available. At the bottom of your dog’s Summary page,  select the “Download Technical Report” button to access your printable report.


What happened to my dog’s Genetic Diversity information? 

Since 2010, preserving and monitoring diversity has been a fundamental part of our breeder products. We’ve redesigned diversity reporting to be as user-friendly as possible for all breeders and to make it available in the new web experience.


Where are the Genetic Relationships graphs? 

We are exploring new and better ways to convey the information in the Genetic Relationships graphs (also known as the MDS graphs). But for the time being, they are not available.


I need to submit results to OFA. How do I do that? 

You may download a printable Technical Report from the Summary page of your results.


What happened to the Breeder Tool? 

To provide a better experience for all customers, we’re consolidating our products onto the same web platform. Due to the technical complexity of supporting the Breeder Tool for our large breeder base, it will not be available in the immediate future. But we are exploring ways to bring this functionality to our customers in future updates and will inform you when more details are available.


I’m a breeder or affiliated with a breed association. Is there a discount code available to me at this time? 

Yes. We will continue to honor existing discounts for clubs that use Optimal Selection™ or MyDogDNA™. Multi-kit discounts are available for all breeder product purchases of four (4) kits or more.


How does your diversity score compare to COI?

The genetic diversity measurement found in Optimal Selection™ is based on genotyping specific single nucleotide polymorphisms (SNPs) of the genome and calculating the times a same (homozygous) or different (heterozygous) variant was inherited from the parents. All heterozygosity calculations in our products have been calculated based on the same SNP panel maintained on our custom microarray chip. This is notable because calculations from different sources can differ slightly due to differences in the marker sets used. 


COI is typically based on recent pedigrees and is associated with the probability of inheriting two copies of the same allele (or sometimes a haplotype, being a large genomic chunk of inherited alleles) from common ancestors. Diversity (or heterozygosity) scoring is based on genetic testing at a number of genomic locations that are informative of overall variability within a population. 


It’s worth noting that measuring genetic diversity is measuring an association with inbreeding, rather than directly measuring inbreeding. In addition to recent family inbreeding, Optimal Selection™ diversity score reflects long-term population “inbreeding” which can be very important in dogs - especially for breeds that have had small, relatively closed populations for many generations. This genetic diversity measurement is most useful when comparing the score against the provided population's score as both were created using the same method and genetic marker set. 


I tested using Optimal Selection™ a few years ago but the new report is missing some tests that were originally reported. Where are they?

The old reports are still available in your account and should have all the tests that were available when the panel was originally processed. To find the original (legacy) report select “manage pet profile” under the dog in question and scroll down to the bottom of the page; the PDF link for the legacy report can be found there. When older tests were migrated to the new platform, only tests that are performed in the same manner now as they were then could be moved over; otherwise the specific test information on the details page would be incorrect. Some of the tests in question are dilute variant 1 (d1) and furnishings (f).